anti materiel if you have the strength requirement met. Also the gun handling perk is a plus with it. anti materiel rifles can easily kill a death claw at great range if you're a good shot. It's basically a 50 cal sniper rifle.It depends on your play style. If you are looking for insanely high damage with a relatively low rate of fire (good if you have a guns skill of at least 90, preferably 100) is the Anti-Material Rifle. If you are looking for crowd control, fairly high damage and a lower skill requirement, go for the Light Machine Gun. Depends on how you built your character and how you like to play - LMG up close, AMR far away.