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your mom

There are a number of charcters who are unkillable for quest reasons or are children, but if you don't count them (you can usually beat them unconcious pretty easily), A super mutant behemoth has the most HP but has no ranged weapons or armor, a behemoth robot has 1000 HP, is armored and has .50 machnieguns, but moves slowly. For the toughest fight nothing really tops Frank Horrigan - he has about 1000 HP but is well armored, fast, can heal, has some kind of super plasma rifle, and you can't hit him for more than 192 HP per attack.

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