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Build to Destroy, Concentrated Fire, Plasma Spaz, Laser Commander...

Meltdown, IF you also concentrate on Melee or Unarmed. The explosions it causes can damage you and your companions, so it is best used from afar. This means you need another, close range combat skill.

You'll also might like to focus in VATS, so perks like Commando, Gunslinger, Sniper. However, these are not crucial to the build.

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