If you mean the crucified ones, no.
the crusified ones cant be saved but the slave ones with collrs can if your good with explosives -spartan- Hso-tage is spelled correctly. He's that Chinese Navajo that Caesar is keeping prisoner.
The slaves in the pen in Cottonwood Cove can be rescued by removing their collars with a high enough explosive skill, and picking the lock on their pen, but to do this you'll need to kill the guards first, because they'll try to stop you or kill the slaves as they escape. Alternately you can talk to Canyon-Runner and buy them from him, and the legion will then let them go.